1. (

• disable ,
• invalid ,
• incapacitate ,
• handicap

) injure permanently; "He was disabled in a car accident" ;

2. (

• handicap ,

) attempt to forecast the winner (especially in a horse race) and assign odds for or against a contestant ;

3. (

• handicap ,
• hinder ,
• hamper

) put at a disadvantage; "The brace I have to wear is hindering my movements" ;